Ortho-ACI™ - Autologous Chondrocyte Implantation

Innovation in Cartilage Repair

Millions of people worldwide suffer pain and limited mobility as a result of damage to articular cartilage, most commonly in the knee or ankle. Unfortunately, unlike muscle or bone, damaged cartilage has a limited capacity for self-repair. Left untreated, the cartilage damage progresses to the point where joint replacement is required.

Orthocell's Autologous Chondrocyte Implantation (Ortho-ACI™) offers an effective treatment for symptomatic defects of the articulating cartilage of the joints. Ortho-ACI™ uses the patient’s own healthy cartilage cells, called chondrocytes, to assist the regeneration of damaged cartilage.

Top left:  Cartilage defect  Top right:  Health cartilage biopsied and sent to Orthocell laboratory  Bottom left:  Cells grown under sterile controlled conditions for 5 weeks  Bottom right:  Cells and scaffold implanted back into repair site to regenerate damaged cartilage.

Top left: Cartilage defect Top right: Health cartilage biopsied and sent to Orthocell laboratory Bottom left: Cells grown under sterile controlled conditions for 5 weeks Bottom right: Cells and scaffold implanted back into repair site to regenerate damaged cartilage.

Key Benefits

ACI was first introduced in 1987, and thousands of implants have been performed world-wide.

The benefits of Ortho-ACI™ are:

  • Clinically validated, with 500+ patients treated using Ortho-ACI™ in Australia, Singapore and Hong Kong.

  • Highly customisable, personalised treatment - each procedure is tailored to the individual patient’s requirements

  • More cost-effective than existing ACI treatments

  • Lower risk than other cartilage regeneration procedures (eg microfracture)

How does Ortho-ACIwork? 

Ortho-ACI™ is a two-stage procedure. The first step involves taking a small piece (a biopsy) of healthy articular cartilage using keyhole surgery. This biopsied tissue is sent off to GMP-licensed laboratory where cartilage cells, called chondrocytes, are isolated and proliferate (increase in number) under controlled conditions for approximately 5 weeks.

Your orthopaedic surgeon will implant the cells into the damaged joint through a small incision or keyhole surgery. The cells are implanted on a custom-designed cellular delivery scaffold. This scaffold creates the optimal environment for the implanted chodrocytes to begin regenerating new cartilage.

A rehabilitation program to slowly increase in weight bearing over a six week period is essential to ensure the success of Ortho-ACI™. Return to sport and recreational activities should also be staged over the first 6-9 months following your Ortho-ACI™ surgery. This staged increase in the intensity of activities protects the newly developing cartilage and allows cartilage maturation process to occur undisturbed.

Patient Information

Ortho-ACI

1.)   10-IFU-10 Ortho-ACI™ Consumer Medicines Information

2.)  Patient information brochure

Publications

October 2018

Journal of Shoulder and Elbow Surgery

Arthroscopic autologous chondrocyte implantation in the glenohumeral joint: a case report

This paper describes the surgical technique and clinical and radiologic outcomes of treatment with Ortho-ACI™ up to 24 months in a 25 year old patient for a symptomatic cartilage defect on the glenoid