Publications
January 2021
International Journal of Case Reports
This case report describes the treatment of a 63-year old female with extensive history of lateral hip pain and treatment-refractory tendinopathy with tearing. The patient underwent open surgery to repair the gluteus medius tendon, using supplementary autologous tenocyte implantation in conjunction with a CelGro collagen scaffold. At 12 months post-treatment, patient had normal function, and MRI scans showed markedly reduced inflammation of the tendon and reduced atrophic changes in muscle belly.
September 2020
Tissue Engineering Part A
Collagen Membrane for Guided Bone Regeneration in Dental and Orthopedic Applications
This paper describes the material characterisation of CelGro collagen membrane, a preclincal model for cortical bone regeneration, and a human study of guided bone regeneration in dental implant surgery. The study showcases the versatility of CelGro as a regenerative medicine scaffold that may be used in different clinical indications.
March 2020
International Journal of Case Reports
Autologous Tenocyte Implantation for the Treatment of Chronic Degenerative Rotator Cuff Tendinopathy
A case report which examines Ortho-ATI® in the treatment of chronic degenerative rotator cuff tendinopathy. The report concludes that Ortho-ATI® has the potential to change the way chronic tendinopathies are managed, whilst also providing a positive option for conservative management of tendinopathy.
November 2018
American Chemical Society
Tissue-level mechanosensitivity: Predicting and controlling the orientation of 3D vascular networks.
A study which examines techniques that improve tissue vascularity orientation and subsequently enhance tissue repair.
October 2018
Biomaterials
This study demonstrates a promising approach of combining a biomaterial scaffold loaded with bone active molecules for guiding cancellous and cortical bone repair.
October 2018
Biomedical Materials
This study aims to develop a bioactive collagen barrier material for guided bone regeneration, coupled with anti-bacterial and anti-inflammatory properties, for use across dental implant applications.
October 2018
Journal of Shoulder and Elbow Surgery
Arthroscopic autologous chondrocyte implantation in the glenohumeral joint: a case report
This paper describes the surgical technique and clinical and radiologic outcomes of treatment with Ortho-ACI™ up to 24 months in a 25 year old patient for a symptomatic cartilage defect on the glenoid.
February 2017
Orthopaedic Journal of Sports Medicine
Clinical study of Ortho-ATI® treatment in patients with chronic gluteal tendinopathy with symptom duration greater than six months, and failure to respond to conservative treatments, including corticosteroid injection. Ortho-ATI® treatment significantly improved clinical outcomes such as pain and disability at 12 and 24 months post treatment.
November 2016
Orthopaedic Journal of Sports Medicine
Lateral Elbow Tendinopathy: Development of a Pathophysiology-Based Treatment Algorithm.
Scientific review article that describes the stages of pathology of tennis elbow. Provides evidence-based, graded treatment principles and associated treatment options for each stage of pathology.
October 2016
The American Journal of Sports Medicine
The study examines the benefits associated with microfracture and autologous matrix-induced chondrogenesis in the treatment of articular cartilage defects.
October 2015
Journal of Orthopaedic Proceedings
Bone substitute with gentamycin leads to new bone cells and growth. Clinical observations with rapid bone formed in the bone substitute, and in some cases in the muscle, are a consequence of both leakage of bone active proteins and also from cells coming from the overlaying muscle interacting with the bone substitute.
April 2015
American Journal of Sports Medicine
This was a clinical study of Ortho-ATI® in patients with tennis elbow, whose symptom duration was greater than six months, and failed to respond to conservative treatments, including corticosteroid injection. Ortho-ATI® treatment significantly improved clinical function (pain, disability and grip strength) and tendon structure for up to 5 years after treatment.
September 2013
American Journal of Sports Medicine
In this study, patients with chronic LE who had previously undergone an unsuccessful full course of nonoperative treatment showed significantly improved clinical function and structural repair at the origin of the common extensor tendon after ATI. This novel treatment is encouraging for the treatment of tendinopathy and warrants further evaluation.
January 2013
BMJ Case Reports
In this clinical case study of Ortho-ATI® treatment for rotator cuff injury in an elite gymnast, the patient reported substantial improvements in pain and function at one year after treatment. MRI scan showed that the tendinopathy had improved with complete healing of the tendon tear.
June 2011
Journal of Tissue Engineering - Part A
Autologous tenocyte treatment (ATT) improved tendon remodeling, histological outcomes, collagen content, and tensile strength of tendinopathic Achilles tendons. This study suggests ATT may be a useful treatment of chronic Achilles tendinopathy.
June 2010
Journal of Shoulder and Elbow Surgery
This study demonstrated that cell death occurs in the ECRB tendon in chronic lateral epicondylitis. The markedly elevated cell death rate in the grade II cell matrix may be responsible for the decrease in cellularity and further deterioration of collagen quality seen in end-stage grade III matrix. This eventually compromised the tendon's ability to maintain its integrity and resulted in tendon tear. The study suggests cell death plays an important role in the development of tendon degeneration in chronic lateral epicondylitis.
June 2007
Journal of Tissue Engineering
This study suggests the implantation of autologous tenocytes on collagen-based bioscaffolds results in better rotator cuff tendon healing and remodeling than with the implantation of bioscaffold alone.