Ortho-ATI™ - Autologous Tenocyte Implantation
For the regeneration of human tendon
Orthocell’s Ortho-ATI™ is a first-in-class cell therapy for treatment of chronic degenerative tendon injuries. Ortho-ATI™ addresses a significant unmet clinical need for a safe, effective and non-surgical solution for a debilitating injury affecting millions of people every year. The unique treatment uses each patient’s own tendon-derived cells to stimulate tendon regeneration and is delivered via ultrasound guided injection under local anaesthetic.
Orthocell has embarked on an evidenced based clinical development program focused on safety and performance in multiple tendon indications, including shoulder, elbow, hip, knee and ankle. Further information about our clinical trials, click here.
Autologous tenocytes injected into the elbow using ultrasound guidance
Key Benefits
Ortho-ATI™ addresses the underlying pathology of tendon injury, replenishing degenerative tissue with healthy mature tendon cells.
The benefits of Ortho-ATI™ are
Accelerated repair of tendon tissue
Minimally-invasive, non-surgical therapy
Cost effective compared to surgery
Patients can return to work, recreational activities and competitive sport in a shorter time
Clinically validated, with 500 + patients treated
82% success rate in treating chronic tendon injuries
Healthy tendon Degenerate tendon
How does Ortho-ATI™ work?
A biopsy of healthy tendon, performed in a doctor's rooms using a local anaesthetic, is sent to our GMP-liscensed laboratory where tendon cells proliferate (increase in number) under controlled conditions. The tendon cells are then implanted by injection into the affected tendon approximately 4 – 5 weeks after the initial biopsy. The injection is given in the doctor's rooms as a walk-in/walk-out procedure.
For more detail about the research and procedure, download our Ortho-ATI™ iBook from the iBookstore and GooglePlay sites below.
Patient testimonials
“Before having the treatment I underwent three lots of surgery and had pretty much accepted I would never be 100% again. I have experienced a 100% recovery, I am pain free, able to exercise and run without issue. I have been able to continue my job as a tactical flight officer”- Patient Dean Allison
“Prior to Ortho-ATI™ I had corticosteroid injections, blood/PRP injections and three separate surgeries and nothing worked. I could not walk 2kms without severe swelling and pain. I was in constant pain every night and for three years I woke at 3am in severe pain. Four weeks after the injection I walked 12km’s, slept soundly and exercised without a limp. I can also run again” - Patient Jane Naughton
Information
for Patients
1.) 10-IFU-09 Ortho-ATI™ Consumer Medicines Information - Download
for Professionals
Publications
January 2018
Physical Therapy in Sport
Autologous Tenocyte Implantation for shoulder tendon pathology in an elite swimmer.
Case report of an elite male swimmer with subscapularis tendon pathology who recieved Ortho-ATI™ treatment after failing conservative management. Post-treatment review by a blinded radiologist demonstrated a significant reduction in tear size and improved tendon morphology. The athlete returned to full training pain free and competed at an international level 4 months post-treatment.
February 2017
Orthopedic Journal of Sports Medicine
Clinical study of Ortho-ATI™ treatment in patients with chronic gluteal tendinopathy with symptom duration greater than six months, and failure to respond to conservative treatments, including corticosteroid injection. Ortho-ATI™ treatment significantly improved clinical outcomes such as pain and disability at 12 and 24 months post treatment.
November 2016
Orthopedic Journal of Sports Medicine
Lateral Elbow Tendinopathy: Development of a Pathophysiology-Based Treatment Algorithm.
Scientific review article that describes the stages of pathology of tennis elbow. Provides evidence-based, graded treatment principles and associated treatment options for each stage of pathology.
April 2015
American Journal of Sports Medicine
This was a clinical study of Ortho-ATI™ in patients with tennis elbow, whose symptom duration was greater than six months, and failed to respond to conservative treatments, including corticosteroid injection. Ortho-ATI™ treatment significantly improved clinical function (pain, disability and grip strength) and tendon structure for up to 5 years after treatment.
June 2014
EFORT Congress - London
Ortho-ATI™ significantly improved clinical outcome in patients with chronic gluteal tendinopathy at 24 months. We remain guarded about the level of efficacy given the small sample size, however this study has shown promise to plan a larger randomised controlled study.
September 2013
American Journal of Sports Medicine
In this study, patients with chronic LE who had previously undergone an unsuccessful full course of nonoperative treatment showed significantly improved clinical function and structural repair at the origin of the common extensor tendon after ATI. This novel treatment is encouraging for the treatment of tendinopathy and warrants further evaluation.
January 2013
BMJ Case Reports
In this clinical case study of Ortho-ATI® treatment for rotator cuff injury in an elite gymnast, the patient reported substantial improvements in pain and function at one year after treatment. MRI scan showed that the tendinopathy had improved with complete healing of the tendon tear.
June 2011
Journal of Tissue Engineering - Part A
Autologous Tenocyte Therapy for Experimental Achilles Tendinopathy in a Rabbit Model
Autologous tenocyte treatment (ATT) improved tendon remodeling, histological outcomes, collagen content, and tensile strength of tendinopathic Achilles tendons. This study suggests ATT may be a useful treatment of chronic Achilles tendinopathy.
June 2010
Journal of Shoulder and Elbow Surgery
This study demonstrated that cell death occurs in the ECRB tendon in chronic lateral epicondylitis. The markedly elevated cell death rate in the grade II cell matrix may be responsible for the decrease in cellularity and further deterioration of collagen quality seen in end-stage grade III matrix. This eventually compromised the tendon's ability to maintain its integrity and resulted in tendon tear. The study suggests cell death plays an important role in the development of tendon degeneration in chronic lateral epicondylitis.
June 2007
Journal of Tissue Engineering
This study suggests the implantation of autologous tenocytes on collagen-based bioscaffolds results in better rotator cuff tendon healing and remodeling than with the implantation of bioscaffold alone.